Methylsulfone polycglorinated biphenyl and 2,2-bis(chlorophenyl)-1,1-dichloroethylene metabolites in beluga whale (Delphinapterus leucas) from the St. Lawrence river estuary and western Hudson bay, Canada

Autor: Derek C. G. Muir, Robert J. Letcher, Pierre Béland, Robert Michaud, Ross J. Norstrom, Krystyna Koczanski, Sylvian De Guise, Courtney D. Sandau
Rok vydání: 2000
Předmět:
Zdroj: Environmental Toxicology and Chemistry. 19:1378-1388
ISSN: 1552-8618
0730-7268
Popis: Kowledge is limited regarding methylsulfone (MeSO2)-polychlorinated biphenyl (PCB), and especially MeSO2–2,2-bis(chlorophenyl)-1,1-dichloroethylene (DDE), metabolites in cetacean species. We hypothesized that the ability of beluga whale (Delphinapterus leucas) to biotransform PCB and DDE compounds, and to form and degrade their MeSO2 PCB and -DDE metabolites, is related to the capacity for xenobiotic metabolism. Adipose biopsies were collected from male and female beluga whale from distinct populations in the St. Lawrence River estuary (STL) and western Hudson Bay (WHB), Canada, which are contrasted by the exposure to different levels of cytochrome P450 enzyme-inducing, chlorinated hydrocarbon contaminants. The PCBs, DDTs, DDEs, 28 MeSO2 metabolites of 14 meta-para chlorine-unsubstituted PCBs, and four MeSO2 metabolites of 4,4′- and 2,4′-DDE were determined. The mean concentrations of total (Σ-) MeSO2-PCB in male STL beluga (230 ng/g), and ratios of Σ-MeSO2-PCB to Σ-PCB (0.05) and Σ-precursor-PCB (0.17) were approximately twofold higher, whereas the Σ-precursor-PCB to Σ-PCB ratio was approximately twofold lower, than in male WHB beluga. Both populations had a low formation capacity for MeSO2-PCBs with ≥six chlorines (
Databáze: OpenAIRE
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