Bone Mineral Density Increases in Trans Persons After 1 Year of Hormonal Treatment: A Multicenter Prospective Observational Study
| Autor: | Paul Lips, Christel J.M. de Blok, Renate T. de Jongh, Annemieke C. Heijboer, Martin den Heijer, Mariska C. Vlot, Maartje Klaver, Guy T'Sjoen, Alessandra D. Fisher, Thomas Schreiner, Nienke M. Nota, Chantal M. Wiepjes |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Urology 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Orthopedics and Sports Medicine Testosterone Femoral neck Bone mineral business.industry Cyproterone acetate medicine.disease Confidence interval 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry business Aromatase deficiency Hormone |
| Zdroj: | Journal of Bone and Mineral Research. 32:1252-1260 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.3102 |
| Popis: | Sex steroids are important determinants of bone acquisition and bone homeostasis. Cross-sex hormonal treatment (CHT) in transgender persons can affect bone mineral density (BMD). The aim of this study was to investigate in a prospective observational multicenter study the first-year effects of CHT on BMD in transgender persons. A total of 231 transwomen and 199 transmen were included who completed the first year of CHT. Transwomen were treated with cyproterone acetate and oral or transdermal estradiol; transmen received transdermal or intramuscular testosterone. A dual-energy X-ray absorptiometry (DXA) was performed to measure lumbar spine (LS), total hip (TH), and femoral neck (FN) BMD before and after 1 year of CHT. In transwomen, an increase in LS (+3.67%, 95% confidence interval [CI] 3.20 to 4.13%, p < 0.001), TH (+0.97%, 95% CI 0.62 to 1.31%, p < 0.001), and FN (+1.86%, 95% CI 1.41 to 2.31%, p < 0.001) BMD was found. In transmen, TH BMD increased after 1 year of CHT (+1.04%, 95% CI 0.64 to 1.44%, p < 0.001). No changes were observed in FN BMD (-0.46%, 95% CI -1.07 to 0.16%, p = 0.144). The increase in LS BMD was larger in transmen aged ≥50 years (+4.32%, 95% CI 2.28 to 6.36%, p = 0.001) compared with transmen aged |
| Databáze: | OpenAIRE |
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