Systematic sorption studies of camptothecin on oxidized single-walled carbon nanotubes

Autor: Tomonori Ohba, Hirofumi Kanoh, Benny Permana, Tsutomu Itoh
Rok vydání: 2016
Předmět:
Zdroj: Colloids and Surfaces A: Physicochemical and Engineering Aspects. 490:121-132
ISSN: 0927-7757
DOI: 10.1016/j.colsurfa.2015.11.020
Popis: Single-walled carbon nanotubes (SWCNTs) have been recognized as promising nanocarriers by many researchers from around the world through hundreds of articles published in the last decade pertaining to SWCNTs-based drug delivery applications. In line with this issue, systematic studies of non-covalent interaction between camptothecin (CPT) and the oxidized SWCNTs (Ox-SWCNTs) have been done in this work. Through the developed process of purification and acid oxidation, we obtained the Ox-SWCNTs that were essentially free of metals and well dispersed in aqueous solutions. A quenching phenomenon, which is indicative of the interactions between CPT and the Ox-SWCNTs, was observed and used as the basis of analysis for monitoring the adsorption of CPT. A comparison of the kinetic models and the overall adsorption capacity was best described by the pseudo second-order kinetic model and Weber–Morris kinetic model. Langmuir and Freundlich models were introduced to fit the adsorption isotherms data. The adsorption of CPT was found to be dependent on concentration and adsorption temperature. The thermodynamic analysis exhibited that the adsorption of CPT on the Ox-SWCNTs was exothermic and spontaneous.
Databáze: OpenAIRE
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