Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects
| Autor: | Felice D'Onofrio, Giuseppe Paolisso, Mariangela Riondino, Michele Varricchio, Maria Tagliamonte, Maria Rosaria Rizzo, Concetta Maria Mone, Carlo Carella, Antonio Gambardella |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Glucose uptake Insulin medicine.medical_treatment Leptin Biology Endocrinology Sex hormone-binding globulin Internal medicine Blood plasma medicine biology.protein hormones hormone substitutes and hormone antagonists Pancreatic hormone Testosterone Hormone |
| Zdroj: | Clinical Endocrinology. 48:291-297 |
| ISSN: | 0300-0664 |
| DOI: | 10.1046/j.1365-2265.1998.00383.x |
| Popis: | OBJECTIVE In humans a sexual dimorphism of plasma leptin concentration has been demonstrated but its significance remains to be established. Sex hormones may have a role. PATIENTS Eighty healthy, non-obese subjects (41M/39F) were studied. MEASUREMENTS In the whole group of subjects plasma sex hormones, leptin and insulin concentrations were determined, body fat content assessed by bioimpedance analysis, body fat distribution evaluated and insulin-mediated glucose uptake measured by euglycemic hyperinsulinemic glucose. RESULTS After adjustment for age, gender, amount of body fat, waist/hip ratio (WHR) and fasting plasma insulin concentration, fasting plasma leptin was still significantly correlated with plasma DHEAS (r =−0.30, P |
| Databáze: | OpenAIRE |
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