| Popis: |
Introduction The Heat Shock Response (HSR) pathway plays a pivotal role in regulating various aspects of fetal Central Nervous System (CNS) development under normal non-stressed conditions. Its disruption, by prenatal exposure to various environmental stressors, hampers fetal neurodevelopment resulting in deficits that are in some cases obvious, such as in Fetal Alcohol Spectrum Disorders (FASD), and in others pernicious, such as an increased predisposition for adult-onset psychiatric illnesses. This chapter explores how stressors, acting alone or with genetic predispositions, can impair the ability of the HSR pathway in facilitating normal fetal neurodevelopment. |
