Automated Dissolution Testing with Flow-Injection Analysis. Dissolution Profiles for the Antiviral Drugs, Dhpg and Acyclovir, in Capsule Formulations

Autor:	Gary C. Visor, Stuart E. Jackson, Richard A. Kenley, John S. Winterle
Rok vydání:	1987
Předmět:	Pharmacology Flow injection analysis Chromatography Chemistry Organic Chemistry Drug Discovery Drug release Pharmaceutical Science Capsule Dissolution testing Dissolution
Zdroj:	Drug Development and Industrial Pharmacy. 13:39-56
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048709040154
Popis:	We have designed, assembled, and tested an automatic dissolution apparatus using flow-injection analysis (FIA) techniques with spectrophotometric detection. The components (pumps, switching valves, detector, and so forth) that comprise the system are all readily-available items used primarily for high-performance liquid chromatography. The system performs well as evidenced by the usual tests for precision, response linearity, and dissolution behavior of standard U.S.P. calibrator (salicylic acid and prednisone) tablets, and offers siqnificant advantages over conventional continuous-flow dissolution testing methods with respect to simplicity, cost, and versatility. Dissolution tests on capsules of the antiviral drugs, DHPG and acyclovir, showed very similar drug release profiles for both formulations.
Databáze:	OpenAIRE
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