Quercetin 3 Rutinoside Facilitates Protection Against Radiation Induced Genotoxic and Oxidative Damage A Study in C57bl 6 Mice
| Autor: | Ajaswrata Dutta, Savita Verma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Chemistry Glutathione Oxidative phosphorylation Pharmacology Malondialdehyde medicine.disease_cause General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound medicine.anatomical_structure medicine Bone marrow General Pharmacology Toxicology and Pharmaceutics General Agricultural and Biological Sciences Quercetin Oxidative stress |
| Zdroj: | Defence Life Science Journal. 6:128-137 |
| ISSN: | 2456-0537 2456-379X |
| DOI: | 10.14429/dlsj.6.16219 |
| Popis: | Radiation-induced oxidative stress and haematopoietic genomic instability is the major concern during planned or unplanned exposure. Use of the natural phytochemicals is an emerging strategy to prevent from the harmful effects of radiation. In the current investigation, Quercetin 3-Rutinoside (Q-3-R), a polyphenolic bioflavonoid, has been evaluated against gamma radiation (2Gy) induced genotoxic damage and oxidative imbalance in mice. Mice were administered with Q-3-R (10mg/kg body weight) 1hr prior to irradiation and evaluated for its antioxidant potential. Anti-genotoxic potential was assessed in terms of chromosomal aberrations in bone marrow cells. Findings revealed that Q-3-R had very high reducing potential, effectively scavenged 1,1-Diphenyl-2-picryl hydrazyl (DPPH) and hydrogen peroxide radicals, chelated metal ions and inhibited lipid peroxidation in a dose dependant manner. The glutathione (GSH) levels were found elevated (p |
| Databáze: | OpenAIRE |
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