Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells
| Autor: | Youssef Rbaibi, Kimberly R. Long, Katherine E. Shipman, Qidong Ren, Catherine J. Baty, Ossama B. Kashlan, Ora A. Weisz |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Molecular Biology of the Cell. 34 |
| ISSN: | 1939-4586 1059-1524 |
| Popis: | CRISPR/Cas9 approaches were used to generate megalin, cubilin, and Dab2 knockouts in polarized proximal tubule cells. Knockout of each component had different effects on endocytic uptake. Data from cell lines and megalin knockout mice support a novel model whereby each protein contributes to driving apical endocytic flux without compromising the physical integrity of the apical endocytic pathway. |
| Databáze: | OpenAIRE |
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