Ozone-induced hypothermia and bradycardia in rats and guinea pigs in nose-only or whole-body inhalation systems
| Autor: | Matthew J. Campen, William P. Watkinson, Rudolph Mebane, Gary E. Hatch, John L. McKee, Joel Norwood |
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| Rok vydání: | 2000 |
| Předmět: |
Bradycardia
medicine.medical_specialty Ozone Inhalation Physiology business.industry Hypothermia Biochemistry Guinea pig chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine Anesthesia Heart rate medicine medicine.symptom General Agricultural and Biological Sciences Whole body business Nose Developmental Biology |
| Zdroj: | Journal of Thermal Biology. 25:81-89 |
| ISSN: | 0306-4565 |
| DOI: | 10.1016/s0306-4565(99)00041-8 |
| Popis: | 1. Ozone (O 3 ) inhalation induces a hypothermic response in rodents characterized primarily by core body temperature ( T CO ) and heart rate (HR) decreases. 2. This preliminary study examined T CO , HR, and electrocardiographic changes in rats and guinea pigs during whole-body or nose-only exposure to 1 ppm 18 O 3 . 3. Rats exposed whole-body demonstrated an immediate hypothermic response, while that of the nose-only exposed rats was delayed ≈60 min; guinea pigs showed no hypothermic response to 18 O 3 . 4. 18 O content in lavage fluid samples suggests that dose is greater in nose-only exposures than whole-body exposures, and that guinea pigs received higher doses than rats. 5. These initial findings suggest that dosimetric differences may result from differences in species responses and exposure scenarios. |
| Databáze: | OpenAIRE |
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