| Popis: |
Primary malignant bone tumors are much less common than benign tumors. The term ‘malignant’ indicates aggressive local growth with the potential to spread (metastasize) to organs beyond the original site of origin. Metastatic carcinomas are the most common malignant tumors involving bone. While bone marrow-derived plasma cell neoplasms (plasmacytoma/multiple myeloma) are the most common primary malignant bone tumor(s), osteosarcoma is the next most common malignant tumor that originates in bone, followed by chondrosarcoma. As in benign bone tumors, there can be significant overlap among the histologic features, but oftentimes these tumors have unique clinical and radiological characteristics. Some tumors involve only certain age groups (i.e., Ewing sarcoma in children/young adults and chondrosarcoma in middle-aged and elderly patients), and some produce only certain changes in bone (i.e., osteoblastic lesions in metastatic prostate cancer). Thus, it is a combination of the clinical, radiographic, and pathological findings that helps determine the diagnosis of bony lesions. |
