| Autor: |
Robert C. Anderson, H.M. Worth, D.G. Hoffman |
| Rok vydání: |
1968 |
| Předmět: |
|
| Zdroj: |
Toxicology and Applied Pharmacology. 12:464-472 |
| ISSN: |
0041-008X |
| DOI: |
10.1016/0041-008x(68)90153-1 |
| Popis: |
The results of this study indicate that α,α-bis-(p-chlorophenyl)-3-pyridinemethanol (EL-241) is a potent inducer of EPN and p-nitroanisole metabolism in weanling male and female rats. Administration of 100 ppm of this compound via the diet results in a significant stimulation of p-nitroanisole O-demethylation within 4 days. Maximum stimulation occurs after 14 days. Removal of the test compound from the diet after 28 days results in the enzyme activities returing to control levels within 28 days. A method for determining no-effect levels for induction of EPN or p-nitroanisole metabolism is also presented. Using this method, the no-effect levels for EL-241 stimulation of p-nitroanisole demethylation in male rats were 26.8 ± 3.3 ppm, 22.3 ± 4.1 ppm, and 23.7 ± 4.0 ppm in three experiments. The no-effect level in female rats was 30.5 ± 3.9 ppm. Although EPN metabolism was stimulated to a greater extent than p-nitroanisole metabolism, the no-effect level for both pathways was the same. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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