Synthesis of the ABCD fragment of gymnocin-B
| Autor: | Renji Ishibashi, Takeo Sakai, Kohei Hata, Yuki Kitamura, Yuji Mori |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Fragment (computer graphics) Stereochemistry Organic Chemistry Iodide Convergent synthesis Ether Alkylation 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Radical cyclization 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Stereoselectivity |
| Zdroj: | Tetrahedron Letters. 60:151261 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2019.151261 |
| Popis: | A convergent synthesis of the ABCD fragment of gymnocin-B was accomplished. The tetracyclic ether ring system was synthesized by the construction of the BC ring system via the oxiranyl anion alkylation and ring expansion reaction, followed by the formation of the five-membered A-ring via a stereoselective radical cyclization reaction of a neopentyl-type iodide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect