Enantiomeric resolution of chiral aromatic sulfoxides on non-commercial cellulose tribenzoate plates

Autor:	Luciano Lepri, Alessandra Cincinelli, Leonardo Checchini, Massimo Del Bubba
Rok vydání:	2012
Předmět:	inorganic chemicals Chromatography Resolution (mass spectrometry) Elution Clinical Biochemistry Biochemistry Analytical Chemistry Microcrystalline cellulose chemistry.chemical_compound Colloid chemistry Organic chemistry Microemulsion Self-assembly Cellulose Enantiomer
Zdroj:	Journal of Planar Chromatography – Modern TLC. 25:214-219
ISSN:	1789-0993 0933-4173
DOI:	10.1556/jpc.25.2012.3.5
Popis:	This paper reports a number of original thin-layer chromatographic enantioseparations of chiral sulfoxides that are important for their use as drugs and drug metabolites, pesticides, or chiral auxiliaries, obtained by elution with alcohols or aqueous-alcoholic mixtures at different ratios on cellulose tribenzoate. Detection was performed by exposing the plates to iodine vapor, followed by densitometry at 410 nm. Under these experimental conditions, ten of the eighteen chiral aromatic sulfoxides investigated were baseline or partially resolved, thus providing useful chromatographic information for this important class of racemic compounds.Data obtained with cellulose tribenzoate were compared to those achieved with microcrystalline cellulose triacetate for the same group of chiral sulfoxides, evidencing an interesting complementary behavior of the two stationary phases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4fe76ee48a0c67e5bbc815613e5df00a https://doi.org/10.1556/jpc.25.2012.3.5 Zobrazit plný text záznamu Full text from SpringerLink