Cognitive Recovery After Stroke: A Meta-analysis and Metaregression of Intervention and Cohort Studies

Autor: Saa, JP, Tse, Tamara, Baum, CM, Cumming, T, Josman, N, Rose, Miranda, O’Keefe, S, Sewell, Katherine, Nguyen, Vinh, Carey, Leeanne
Rok vydání: 2021
Předmět:
DOI: 10.26181/60f7c24d6f544
Popis: Background: Cognition affects poststroke recovery, but meta-analyses of cognition have not yet provided a comparison of observational and intervention evidence. Objective: To describe the trajectory of poststroke cognition and the factors that moderate it across intervention and observational cohorts. Methods: Six databases were searched up to January 2020. Studies describing quantitative changes in cognition in adults poststroke were included. Interventions were classified into pharmacological, therapist-led, nonroutine/alternative, and usual care. Summary estimates were compared via hierarchical mixed-effects models. Age, recovery stage, stroke etiology, cognitive domain targeted in studies, and intervention types were investigated as moderators of cognition. Recovery stage and intervention were further analyzed in a multiplicative metaregression model. Results: A total of 43 intervention trials and 79 observation cohorts involving 28 222 stroke participants were included. Heterogeneity was significant (τ = 0.09; CI = 0.01-0.21, P
Databáze: OpenAIRE