Abstract 12816: Epicardial Adipose Tissue Around the Left Atrium is Associated With Atrial Fibrosis in Patients With Atrial Fibrillation

Autor: Bahareh Askari-Atapour, Kristen Kwan, Carter A Anderson, Mahbod Jafarvand, Zeinab Birjandian, Deanna Tregoning, Patrick M Boyle, Nazem W Akoum
Rok vydání: 2021
Předmět:
Zdroj: Circulation. 144
ISSN: 1524-4539
0009-7322
Popis: Background: Obesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Left atrial epicardial fat (LAEF) may be a link to these associations. Objective: We sought to assess whether LAEF is associated with atrial fibrosis and BMI (Body Mass Index). Methods: Patients with atrial fibrillation undergoing catheter ablation were assessed with cardiac MRI for overall epicardial fat, LAEF, and fibrosis quantification. Epicardial fat was imaged using a 3-dimensional Dixon sequence and quantified by contouring regions of fat on axial images (Panel A; Blue regions represent LAEF). Atrial fibrosis was quantified from the Late Gadolinium Enhancement (LGE) MRI. Image registration was used to assess the relationship between left atrial epicardial fat and left atrial fibrosis. Results: 45 patients underwent the imaging protocol (64±10 years; 76% male). BMI was 29.3±6.1 kg/m 2 , LAEF was 248±155 cm 2 , and LA fibrosis was 17.4±8.4%. LAEF was significantly correlated with both LA fibrosis (Fig B; P=0.017; R 2 =0.125) and BMI (y[BMI] = 0.093x[LAEF] + 5.37; p=0.01, R 2 =0.155). Total epicardial fat was also correlated with BMI (y[BMI] = 0.014x[total epicardial fat] + 9.01; p2 =0.33). The overlap of LAEF and fibrosis was moderate with a Dice coefficient ranging from 0.26 to 0.49. (Fig C). Conclusion: LAEF is associated with obesity (BMI) and LA fibrosis with a moderate degree of colocalization. These findings support a role for LAEF as a contributor to atrial fibrosis and a link between obesity and atrial fibrillation.
Databáze: OpenAIRE
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