| Autor: |
Andreas Wieser, Esayas Kebede Gudina, Guenter Froeschl, Beza Eshetu, Mulatu Gashaw, Netsanet Workneh, Guro K. Bårnes, Getnet Tesfaw, Solomon Ali, Melkamu Berhane |
| Rok vydání: |
2019 |
| Předmět: |
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| DOI: |
10.21203/rs.2.19534/v1 |
| Popis: |
Background : Tackling neonatal infections and antibiotic resistance remains a challenge in low-income countries where neonatal mortality is high and antibiotic resistance is growing. The aim of this study was to identify bacterial etiologies and their drug resistance patterns in neonates admitted with diagnosis of sepsis to neonatal intensive care unit at Jimma Medical Center in Ethiopia. Methods : A prospective longitudinal study was conducted from April to October 2018. A total of 313 clinical specimens (211 blood and 102 cerebrospinal fluid) were processed for 238 neonates suspected to have sepsis. Blood culture was done using BD BACTEC FX40 automated system. Bacterial identification and antibiotic susceptibility testing were done according to standard microbiological techniques. Results : Bacterial etiologies were isolated from 62.1% (131/211) and 3.9% (4/102) of blood and cerebrospinal fluid cultures respectively. The predominant bacteria isolated from blood were Coagulase negative Staphylococcus 27.5% (36/131), followed by S. aureus 20.6% (27/131), Klebsiella species 14.5% (19/131), and Acinetobacter species 10.7% (14/131). Nearly 85% of the isolates were multidrug resistant, predominantly observed in Gram-negative bacteria. Among locally available antibiotics, only meropenem for Gram-negatives and vancomycin for Gram-positives were found to be largely effective. Conclusion : Bacterial pathogens identified in the study were highly resistant to available antibiotics. Thus, an effort to reduce neonatal mortality in the setting should focus on improving diagnostics for neonatal infection and containment of antimicrobial resistance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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