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Publisher Summary This chapter reviews the immunological competence of lymphocytes that were infected in vitro with measles. Experiments described in the chapter were performed to test whether supernatants of stimulated, virus-infected lymphocytes were inhibitory and, if so, whether this inhibition could be accounted for by measles virus or virus-induced inhibitory substances, that is, interferon. When supernatants of PHA-stimulated measles virus-infected lymphocyte cultures were added to a final concentration of 16% to fresh PHA-stimulated lymphocyte cultures from the same individual, a complete inhibition was observed. This effect was UV-light sensitive and could be removed by ultracentrifugation, indicating that virus-induced interferon was probably not responsible for the observed inhibition, because it is well known that interferon is not sensitive to UV light. The results show that live measles virus suppresses stimulation of lymphocytes by both specific and nonspecific stimuli and that this inhibition is not because of interferon. |
