Hypertension and Type 2 Diabetes Mellitus as Risk Factors for Prostate Cancer Patients in Southern Nigerians

Autor: Dr. John E. Raphael, Ngozi Ekeke
Rok vydání: 2022
Předmět:
Zdroj: Saudi Journal of Biomedical Research. 7:101-106
ISSN: 2518-3222
2518-3214
DOI: 10.36348/sjbr.2022.v07i02.006
Popis: Background: Prostate cancer (PCa) is one of the most commonly diagnosed cancers in Nigerian men and worldwide. Some comorbidities, such as hypertension, diabetes, and cardiovascular diseases have been investigated as potential risk factors for developing PCa. Hypertension and Type2 diabetes mellitus (DM) are common with the middle age and elderly and could be a conundrum during treatment. Aims and Objectives: This study highlights the associated comorbidities with prostate and describes the relationship between Type 2 Diabetes Mellitus and hypertension with prostate cancer among southern Nigerian men. Materials and Methods: This was a retrospective study carried out over ten years ago on all patients with histologically confirmed prostate cancer at the University of Port Harcourt and two other private urology hospitals from where the study population was evaluated. The folders were retrieved and their age, prostate-specific antigen levels, Gleason grade, comorbidities, and treatment received were analyzed. Patients with incomplete data were excluded from the study. The data were collated using Microsoft excel 2020. Data collected were then analyzed using SPSS version 20. Results: There were a hundred and fifty-two patients with histologically confirmed PCa. Sixty-four were reported with a known Gleason score fifty-four (35.5%) of the patients had no associated comorbidity. Hypertension was the commonest associated comorbidity seen in sixty-one (40.1%) of the patients, followed by Type 2 Diabetes Mellitus in nineteen (12.5%). The poorly differentiated cancers were commonest among the patients with hypertension, Type 2 DM, and patients with both. There was no association between Type 2 DM, hypertension, and Gleason’s score. Conclusion: Diabetes and hypertension are still the commonest comorbidities associated with Prostate cancer. There is no statistically significant association was found between Gleason’s score, diabetes, and hypertension in patients with prostate cancer.
Databáze: OpenAIRE
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