P3‐182: Identification of target engagement biomarkers for MARK inhibitor discovery using quantitative mass spectrometry
| Autor: | Hugh Nuthall, Shang-Shuan Yu, Ron Hendrickson, An Chi, Cloud P. Paweletz, Alan B. Northrup, Mansuo Hayashi |
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| Rok vydání: | 2010 |
| Předmět: |
Antioxidant
Epidemiology business.industry Health Policy Vitamin E medicine.medical_treatment Target engagement Oxidative phosphorylation Oxidative damage Psychiatry and Mental health Cellular and Molecular Neuroscience Developmental Neuroscience medicine Cancer research Neurology (clinical) Geriatrics and Gerontology business Intracellular |
| Zdroj: | Alzheimer's & Dementia. 6 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2010.05.1680 |
| Popis: | decrease in intracellular vitamin E was associated with the deterioration in cognitive performance. The correlation between oxidative changes and mitochondral dysfunction will be established. Conclusions: These results suggest that accumulation of oxidative damage may start in pre-symptomatic phases of AD pathology and that progression to AD might be related to deplection of antioxidant defenses. This work was supported by the Portuguese Foundation for Science and Technology (FCT) through PIC/ IC/83206/2007 |
| Databáze: | OpenAIRE |
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