Hypokalemia and suspected renal tubular acidosis associated with topical carbonic anhydrase inhibitor therapy in a cat

Autor: Charlotte E. Thiessen, R. David Whitley, Kyle L. Tofflemire, Kelly M. Makielski, Gil Ben-Shlomo, Rachel A. Allbaugh
Rok vydání: 2015
Předmět:
Zdroj: Journal of Veterinary Emergency and Critical Care. 26:870-874
ISSN: 1479-3261
DOI: 10.1111/vec.12417
Popis: Objective To describe the occurrence of hypokalemia, metabolic acidosis, and suspected renal tubular acidosis associated with the administration of topical ophthalmic carbonic anhydrase inhibitor (CAI) in a cat. Case Summary A 2-year-old, 5.3 kg, male, castrated, domestic short-haired cat developed hyporexia 6 weeks after starting topical ophthalmic dorzolamide 2% therapy for treatment of ocular hypertension. Two weeks later, the cat was evaluated for severe weakness, cervical ventroflexion, and anorexia. Plasma electrolyte and acid–base measurement revealed hypokalemia (K+ = 2.9 mmol/L; reference interval 3.8–5.4 mmol/L) and metabolic acidosis (plasma HCO3− = 9.8 mmol/L; reference interval 15–23 mmol/L) in the presence of a urine pH of 7.5 (reference interval 6.5–7.5). The pH abnormalities were consistent with a renal tubular acidosis. Clinical and biochemical abnormalities resolved with short-term supportive care, potassium supplementation, and discontinuation of dorzolamide therapy. New or Unique Information Provided This is the first report of hypokalemia and metabolic acidosis associated with topical CAI therapy in a cat.
Databáze: OpenAIRE
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