| Autor: |
Madeeha Awan, Muhammad Sheeraz Ahmad, Ammad Ahmad Farooqi, Muhammad Ismail, Sobia Kanwal, Edyta Pawlak-Adamska, Oskar Nowak, Aliye Aras Perk, Mirna Azalea Romero, Riffat Batool, Qaisar Mansoor |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Molecular Oncology: Underlying Mechanisms and Translational Advancements ISBN: 9783319530819 |
| DOI: |
10.1007/978-3-319-53082-6_7 |
| Popis: |
Hepatocellular carcinoma is a multifaceted and genomically complex disease and rapidly emerging experimental evidence has started to shed light on wide ranging molecular mechanisms which underlie its development and progression. It is now known that Overexpression of oncogenes, inactivation of tumor suppressor genes, dysregulation of spatio-temporally controlled intracellular signaling cascades, genetic/epigenetic mutations, loss of apoptosis and intra-tumor heterogeneity contribute significantly. Research over the years has gradually revealed intricate role of intracellular signaling cascades both in growth, development and cancer. Misrepresentation of EGFR induced intracellular signaling has been shown to fuel cancer development and progression. We partition this review into how EGFR modulates protein machinery in hepatocellular carcinoma and also summarize most recent updates on preclinical and clinical trials. Better and deeper understanding of the molecular mechanisms of HCC will be helpful in getting a step closer to individualized medicine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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