Trace eyeblink conditioning in the freely moving rat: Optimizing the conditioning parameters

Autor:	Craig Weiss, John F. Disterhoft, R. I. Patel, John M. Power, Matthew S. O'Connor, M. G. Knuttinen
Rok vydání:	1999
Předmět:	Test battery Behavioral Neuroscience Electrophysiology Environmental lighting Eyeblink conditioning BROWN NORWAY Conditioning Classical conditioning Stimulus (physiology) Psychology Neuroscience
Zdroj:	Behavioral Neuroscience. 113:1100-1105
ISSN:	1939-0084 0735-7044
DOI:	10.1037/0735-7044.113.5.1100
Popis:	Trace eyeblink conditioning (EBC) parameters, with an airpuff unconditioned stimulus, were examined in male Fischer 344 X Brown Norway F1 rats. Integrated electromyographic activity from the upper eyelid was recorded. An 8-kHz tone was superior to white noise as a conditioning stimulus. Rats trained with 30 or 50 trials per session showed similar learning. Reversal of environmental lighting had no significant effect. Trace intervals of 0 and 250 ms yielded well-timed conditioned responses (CRs); intervals of 500 ms or more did not. These experiments provide parameters that reliably yield CRs and suggest limits on the temporal processing capabilities of the rat. EBC can thus be used as part of a comprehensive test battery for learning and memory in this species. Physiological recording and pharmacological manipulations may also be done easily. This combination of approaches should facilitate a more complete understanding of learning mechanisms and age-related memory impairments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4cd4d198edff4cdf571aaf57e6d29160 https://doi.org/10.1037/0735-7044.113.5.1100 Zobrazit plný text záznamu