Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III)

Autor:	Thomas F. Walsh, Nancy A. Nolan, Douglas J. Pettibone, William J. Greenlee, Stacey O'Malley, Raymond S.L. Chang, Kenneth J. Fitch, D. F. Veber, David L. Williams, Kathryn L. Murphy, Bradley V. Clineschmidt
Rok vydání:	1995
Předmět:	Angiotensin receptor Chemistry Ligand binding assay Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Biochemistry Angiotensin II Part iii Drug Discovery Molecular Medicine Endothelin receptor Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1155-1158
ISSN:	0960-894X
Popis:	Screening a collection of α-phenoxyphenylacetic acid derived angiotensin II antagonists identified weak actives in an endothelin receptor binding assay. Synthetic modification of one of these leads has provided L-746,072 (13), a highly potent dual antagonist of angiotensin II and endothelin receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4cbeefcb6363c63409cfc7f93562c70e https://doi.org/10.1016/0960-894x(95)00186-w Zobrazit plný text záznamu Full Text from ScienceDirect