Autor: |
Thomas F. Walsh, Nancy A. Nolan, Douglas J. Pettibone, William J. Greenlee, Stacey O'Malley, Raymond S.L. Chang, Kenneth J. Fitch, D. F. Veber, David L. Williams, Kathryn L. Murphy, Bradley V. Clineschmidt |
Rok vydání: |
1995 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 5:1155-1158 |
ISSN: |
0960-894X |
Popis: |
Screening a collection of α-phenoxyphenylacetic acid derived angiotensin II antagonists identified weak actives in an endothelin receptor binding assay. Synthetic modification of one of these leads has provided L-746,072 (13), a highly potent dual antagonist of angiotensin II and endothelin receptors. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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