Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins

Autor:	Oleg N. Chupakhin, Vladimir V. Egorov, E. G Deeva, Vladimir L. Rusinov, Oleg I. Kiselev, Andrey V. Vasin, Irina M. Sapozhnikova, N. R. Medvedeva, Evgeny N. Ulomskii
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Substitution reaction chemistry.chemical_compound Chemistry Stereochemistry Nucleophilic aromatic substitution Organic Chemistry Nitro Nucleophilic substitution Thiol Acid hydrolysis Glutathione Cysteine
Zdroj:	Chemistry of Heterocyclic Compounds. 51:275-280
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-015-1695-4
Popis:	The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4c8ade13cfc7456cd37015af8984befd https://doi.org/10.1007/s10593-015-1695-4 Zobrazit plný text záznamu Full text from SpringerLink