Mediastinal Tuberculosis Lymphadenitis during Anti-TNF Therapy - Case Report

Autor: Bruno César da Silva, Fabio Carneiro Vosqui Nascimento, Tatiana Senna Galvão Nonato Alves, Valdiana Surlo, Genoile Oliveira Santana, Eduardo Antonio Gonçalves Ramos, Sonyara Lisboa
Rok vydání: 2015
Předmět:
Zdroj: Archives of Clinical Gastroenterology. 1:038-040
ISSN: 2455-2283
Popis: Tuberculosis is described during the use of monoclonal antibodies against tumour necrosis factor (TNF) for Crohn's disease treatment. We report a case of a 44 year old man that developed fever, night sweats and weight loss during immunosuppressive and anti-TNF therapy for Crohn's disease. After extensive investigation we performed mediastinoscopy with biopsy of the paratracheal lymph node. A histopathological study revealed caseous necrosis. The patient improved after therapy against tuberculosis. During anti-TNF therapy, the diagnosis of tuberculosis may be mainly difficult when an atypical location is present. Clinical skills are important mainly in countries where tuberculosis is endemic.
Databáze: OpenAIRE