Stimulation of serotonin (5-HT) activity reduces spontaneous stereotypies in female but not in male bank voles (Clethrionomys glareolus)
| Autor: | B Schoenecker, Knud Erik Heller |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Citalopram medicine.disease behavioral disciplines and activities Endocrinology Food Animals Mood disorders Stereotypy Internal medicine mental disorders medicine Antidepressant Anxiety Animal Science and Zoology Serotonin medicine.symptom Psychology 5-HT receptor Clozapine Clinical psychology medicine.drug |
| Zdroj: | Applied Animal Behaviour Science. 80:161-170 |
| ISSN: | 0168-1591 |
| DOI: | 10.1016/s0168-1591(02)00210-1 |
| Popis: | Spontaneously stereotyping female and male bank voles were injected daily (except on days assigned for monitoring behaviour) during 3 weeks with placebo, the neurolepticum clozapine or the SSRI antidepressant citalopram. Clozapine blocks dopamine (DA) receptors and acts as a partial serotonin (5-HT) antagonist, while citalopram is a specific 5-HT agonist. Stereotypies in both sexes were left unaffected by clozapine treatment, but citalopram markedly reduced stereotypy levels in females. Animal stereotypies have been widely used in models to provide insight into the underlying pathophysiological processes in human mental disturbances. The present findings highlight the importance of examining sex as a significant variable in evaluating responses to pharmacotherapy, and the demonstrated effect of citalopram indicates that stereotyping female bank voles may be useful in new animal models for human anxiety and mood disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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