Effect of pulmonary vein isolation on atrial arrhythmogenic substrates in atrial fibrillation
| Autor: | Keijiro Saku, Hiroo Noguchi, Koichiro Kumagai, Tomoo Yasuda, Masahiro Ogawa |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
P wave dispersion
medicine.medical_specialty Isolation (health care) medicine.diagnostic_test business.industry P wave Atrial fibrillation medicine.disease Electrocardiographic lead Pulmonary vein Atrial depolarization Physiology (medical) Internal medicine Cardiology Medicine Cardiology and Cardiovascular Medicine business Electrocardiography |
| Zdroj: | Heart Rhythm. 2:S222 |
| ISSN: | 1547-5271 |
| DOI: | 10.1016/j.hrthm.2005.02.693 |
| Popis: | Background: It has been reported that pulmonary veins (PVs) have a major role in initiation or maintainance of atrial fibrillation (AF) and PV isolation is effective therapy to modify atrial arrhythmogenic substrates for AF elimination. However, its mechanism remains unclear. Methods and Results: We performed P-wave signal-averaged electrocardiography with P-wave-triggering method from the 12 standard electrocardiographic lead in 15 patients with paroxysmal or persistent atrial fibrillation. We measured maximum P-wave duration (PWD), minimum PWD, P wave dispersion among 12 leads and before and after PV isolation. Maximum and minimum PWD after PV isolation were significantly shorter than those before PV isolation (163.6 9.3 to 153.1 9.2 ms, P 0.0001, 141.6 9.8 to 135.9 9.3 ms, P 0.0001, respectively). P wave dispersion was significantly smaller than that before PV isolation (25.9 7.0 to 20.1 6.0 ms, P 0.0001). LP20 significantly increased after PV isolation compared with that before PV isolation (1.8 1.5 to 3.0 2.2 V, P 0.0001). Conclusion: Pulmonary vein isolation may contribute improvement of atrial arrhythmogenicity due to shortening and homogeneity of atrial depolarization and reduction of atrial conduction delay. |
| Databáze: | OpenAIRE |
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