| Popis: |
Complex regional pain syndrome (CRPS) is a complex neuropathic pain syndrome. It is a challenging clinical entity, and the name for this illness as well as the classification system has evolved over time. Pain is the hallmark of this illness, particularly when disproportionate to what should be expected, along with atypical symptoms that may or may not include autonomic dysfunction. The disease course has been described as having an “acute” initial stage with progression to a “chronic” or “trophic” stage, although more recent data suggest that there may actually be three different subtypes of CRPS with different clinical features. Both a central and a peripheral sensitization component are believed to be involved in the pathophysiology of CRPS, although the exact mechanism is not well known. Clinical presentations for CRPS may vary from patient to patient, and characteristic signs and symptoms can be classified as sensory, vasomotor, sudomotor/edema, and motor/trophic. A thorough history and physical examination are critical to evaluate for findings that may correlate with diagnostic criteria. The burden of illness for patients with CRPS is significant and may require long-term medical treatment. Resolution may occur in some cases; complications of pain, limited range of motion, atrophy, contractures, and abnormal sensation may develop. |
