Hepatitis B virus infection in patients with idiopathic liver disease
| Autor: | Rafael Enat, Jack R. Wands, Hubert E. Blum, Nancy V. Brown, Yaacov Baruch, Lucyna Bassan, Nurit Rimon, Edna Ben-Porath, T. Jake Liang |
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| Rok vydání: | 1991 |
| Předmět: |
Hepatitis B virus
medicine.medical_specialty HBsAg Hepatology biology business.industry Hepatitis C virus medicine.disease_cause biology.organism_classification Chronic liver disease medicine.disease Virology digestive system diseases Virus Liver disease Hepadnaviridae Internal medicine Immunology medicine business |
| Zdroj: | Hepatology. 13:1044-1051 |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | We studied 67 HBsAg-negative Israeli patients (36 negative for all HBV serological markers as group 1 and 31 positive for antibodies to HBs and HBc as group 2) with chronic liver disease and cirrhosis of unknown origin using a rapid, sensitive and specific assay for the detection of low levels of hepatitis B virus in serum. This technique uses a high-affinity monoclonal antibody to HBs against an a domain epitope of HBsAg to capture the virion, followed by hepatitis B virus DNA amplification with the polymerase chain reaction. In addition, 55 subjects without liver disease served as controls: Group 3 (n = 32) was negative for all hepatitis B virus markers; group 4 (n = 23) was positive for antibodies to HBs and HBc. We found 11 individuals in group 1 (31%) and 10 in group 2 (29%) harboring low levels of hepatitis B virus DNA in serum. In contrast, no one in group 3 or group 4 was positive by this technique (p 30%). We conclude that infection with hepatitis B virus undetectable by conventional assays and with hepatitis C virus may represent important unrecognized causes of idiopathic chronic liver disease in Israel, accounting for the possible origin in more than 90% of patients. (HEPATOLOGY 1991;13:1044–1051.) |
| Databáze: | OpenAIRE |
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