DOP25 Medication use and comorbidities among elderly when compared with younger patients with inflammatory bowel disease in the TARGET-IBD cohort
| Autor: | Corey A. Siegel, Miguel Regueiro, Julie M. Crawford, Edward L. Barnes, Derek Gazis, Marla Dubinsky, Bruce E. Sands, David T. Rubin, Mph Millie D. Long Md, J Hanson, Sumona Saha |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Crohn's disease Necrosis Thiopurine methyltransferase biology business.industry Gastroenterology General Medicine medicine.disease Inflammatory bowel disease Comorbidity Ulcerative colitis Internal medicine Cohort medicine biology.protein medicine.symptom Adverse effect business |
| Zdroj: | Journal of Crohn's and Colitis. 14:S063-S066 |
| ISSN: | 1876-4479 1873-9946 |
| Popis: | Background When compared with younger patients, much less is known regarding inflammatory bowel disease (IBD)-related medications in the elderly (>65 years) patients. This analysis uses a large cohort of patients with IBD to describe the distribution of patient characteristics and patterns of medication use. Methods TARGET-IBD is a longitudinal cohort of patients with IBD receiving usual care at community and academic practices in the US. Patients with IBD enrolled between July 2017 and May 2019 were included in this analysis. The prevalence of medication use by drug class at the time of enrolment among patients with both ulcerative colitis (UC) and Crohn’s disease (CD) was estimated. Age was stratified into the following categories: 65 years. Proportions and means of patient characteristics were compared using tests of association. The odds of biologic use at enrolment was modelled as was the 95% CI by patient characteristics using logistics regression. Results 681 patients with UC and 979 patients with CD were included in the analysis. At enrolment, mesalamine was the most common medication used among patients with CD >65 years (34%) and among patients with UC across all age categories (58%–77%, Table 1). The use of mesalamine generally increased with advancing age. Patients with CD >65 years were more than twice as likely to be users of mesalamine at enrolment than patients 65 years compared with patients 65 at enrolment, use of a 5-ASA derivative, anti-TNF, steroid, or thiopurine did not differ by established and newly diagnosed patients. There was no association between age, type of IBD, insurance, gender, race or cardiovascular disease and the odds of biologic use in patients >65 years (Figure 1). Conclusion Elderly patients with IBD, whether those with new diagnoses or individuals with the longstanding disease make up a substantial portion of the IBD population. Given that elderly patients demonstrate significant differences in medication use patterns compared with younger patients with IBD, studies of efficacy and adverse events specific to this population are warranted. |
| Databáze: | OpenAIRE |
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