Synthetic Analogues of 15,15-Acetals of Prostaglandin F2α and E2
Autor: | Václav Kozmík, Jaroslav Paleček |
---|---|
Rok vydání: | 1994 |
Předmět: | |
Zdroj: | Collection of Czechoslovak Chemical Communications. 59:2533-2544 |
ISSN: | 1212-6950 0010-0765 |
DOI: | 10.1135/cccc19942533 |
Popis: | Two series of 15,15-ethyleneacetals of PG F2α and PG E2 modified both in the α- and ω-chains were prepared with a view to find more stable and efficient analogues of this type. The synthesis of the analogues starting from the easily available (±)-[(3aα,4α,5β,6aα)]-5-(1,1'-biphenylyl-4-carbonyloxy)-4-formylhexahydro-2H-cyclopenta[b]furan-2-one, the so-called Corey aldehyde I, was based on conventional procedures, some of which were modified to achieve the optimum yields. |
Databáze: | OpenAIRE |
Externí odkaz: |