ChemInform Abstract: Endothelin Receptor Antagonist Triterpenoid, Myriceric Acid A, Isolated from Myrica cerifera, and Structure Activity Relationships of Its Derivatives

Autor:	Junko Kikuchi, Yuji Ikenishi, Yoshihiro Terui, Kensuke Sakurawi, Kazuhiro Takahashi, Toshiro Konoike, Takehiko Tozyo, Tomohiro Sato, Shin-ichi Mihara, Miharu Nakamura, Fumio Yasuda, Masafumi Fujimoto, Tsuyoshi Iwata
Rok vydání:	2010
Předmět:	Terpene Cytosol Sulfation biology Chemistry Endothelin receptor antagonist Stereochemistry Chemical modification General Medicine Endothelin receptor biology.organism_classification IC50 Myrica cerifera
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199633208
Popis:	As the first non-peptide endothelin receptor antagonist form a higher plant, a new triter penoid, myiceric acid A (50-235) (1) was isolated from the bayberry, Myrica cerifera. myriceric acid A (1) inhibited not only an endothelin-1-induced increase in cytosolic free Cag2+> concentration (IC50=11±2nM) but [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4a93b918cd860d87273817ef7c0b2594 https://doi.org/10.1002/chin.199633208 Zobrazit plný text záznamu Plný text