The anatomy of mammalian sweet taste receptors
| Autor: | Jérôme Golebiowski, Serge Antonczak, Sébastien Fiorucci, Jean-Baptiste Chéron |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chemistry Sweet taste Class C GPCR Biochemistry Homology (biology) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Structural Biology Metabotropic glutamate receptor Single point Receptor Molecular Biology Receptor activation 030217 neurology & neurosurgery G protein-coupled receptor |
| Zdroj: | Proteins: Structure, Function, and Bioinformatics. 85:332-341 |
| ISSN: | 0887-3585 |
| Popis: | All sweet-tasting compounds are detected by a single G-protein coupled receptor (GPCR), the heterodimer T1R2-T1R3, for which no experimental structure is available. The sweet taste receptor is a class C GPCR, and the recently published crystallographic structures of metabotropic glutamate receptor (mGluR) 1 and 5 provide a significant step forward for understanding structure-function relationships within this family. In this article, we recapitulate more than 600 single point site-directed mutations and available structural data to obtain a critical alignment of the sweet taste receptor sequences with respect to other class C GPCRs. Using this alignment, a homology 3D-model of the human sweet taste receptor is built and analyzed to dissect out the role of key residues involved in ligand binding and those responsible for receptor activation. Proteins 2017; 85:332-341. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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