Chemical modifications of 1→4-2-amino-2-deoxy-α-d-galactan

Autor:	Betty Matsuhiro, Luis E. Lillo
Rok vydání:	2003
Předmět:	Polymers and Plastics biology Chemistry Stereochemistry Organic Chemistry Chemical modification Galactan Caproic Acid chemistry.chemical_compound Residue (chemistry) Amide Galactosamine Materials Chemistry biology.protein Bovine serum albumin Carbodiimide
Zdroj:	Carbohydrate Polymers. 51:317-325
ISSN:	0144-8617
DOI:	10.1016/s0144-8617(02)00188-1
Popis:	Oxidation of 1→4-2-amino-2-deoxy-α- d -galactan (poly-α- d -galactosamine) with nitrogen oxides allowed the formation of a carboxyl group at the C-6 position. The carboxylated polysaccharide by acetylation afforded a derivative similar to the antigenic Vi polysaccharide of Salmonella typhi. The reaction of the modified poly-α- d -galactosamine with caprolactam assisted by carbodiimide introduced at the C-6 position a secondary amide function with a new terminal acidic group. The caproic acid residue was used as a linker for the conjugation of the modified poly-α- d -galactosamine with tetanus toxoid and with bovine serum albumin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4838fb6015fcfd9453fcfc5166bb8788 https://doi.org/10.1016/s0144-8617(02)00188-1 Zobrazit plný text záznamu Full Text from ScienceDirect