| Autor: |
Nakagawa Yoshinori, Niijima Takehiro, Ojima Hiroshi, Terada Hiroshi, Hori Hitoshi |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Oxygen Transport to Tissue XIV ISBN: 9781461365167 |
| DOI: |
10.1007/978-1-4615-3428-0_27 |
| Popis: |
Active oxygen species are involved in both normal cellular processes and in a wide spectrum of pathologies. Hydroxyl radicals (•OH) are highly reactive oxygen species that are likely to cause cellular damage. Superoxide (•O2 −) and hydrogen peroxide (H2O2) are frequently formed in biological systems and participates in reactions that produce •OH, if iron ions are present. Cyanine dyes are known to have biologically acitve properties, the mechanism of which have been suggested to involve oxygen-derived species.1–3 To estimate the possibility of using cyanine dyes as probes to identify these active oxygen species, especially •OH and •C2 −, we studied the bleaching of the dyes in a controlled Fenton reaction [Fe (II) and H2O2]. The Fenton reaction was originally proposed as a chemical source of •OH and also as a biological source of hydroxyl radicals and a likely cause of free radical-induced tissue damage.4,5 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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