Olivocochlear system plasticity in response to chronic noise
Autor: | Omobolade Odedoyin, Katrina M. Schrode, Hamad Javaid, Victoria Gellatly, Amanda M. Lauer, Michael A. Muniak, Matthew A. Xu-Friedman, Dillan F. Villavisanis |
---|---|
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Acoustics and Ultrasonics Olivocochlear system Period (gene) Efferent Biology Synaptic vesicle Background noise 03 medical and health sciences Noise 030104 developmental biology 0302 clinical medicine Endocrinology Arts and Humanities (miscellaneous) Internal medicine Myosin medicine Immunohistochemistry 030217 neurology & neurosurgery |
Zdroj: | The Journal of the Acoustical Society of America. 144:1935-1935 |
ISSN: | 0001-4966 |
Popis: | Plasticity in the medial and lateral olivocochlear (MOC and LOC) systems in response to chronic exposure to background noise was investigated. Three different age-groups of young mice were exposed to the same chronic moderate noise conditions with either immediate tissue harvest or harvest following restoration to quiet conditions, with age matched controls. Cochleae were dissected and standard immunohistochemistry protocols were used to label hair cells with antibodies against myosin 6 and olivocochlear synaptic terminals with synaptic vesicle protein 2 (SV2). Specimens were imaged using confocal microscopy, and density of SV2 labeling was quantified. There was no statistically significant difference in MOC SV2 density between mice raised in noise and age matched controls for any group. However, there was a statistically significant increase in LOC SV2 density for adult mice raised in noise, particularly at higher frequency regions. This could suggest a protective upregulation of the efferent system against chronic moderate noise exposure. The increase in LOC innervation persisted for juvenile mice raised in noise with subsequent restoration to quiet conditions. These data suggest that the LOC system demonstrates sound-dependent plasticity, but that synaptic morphology may be altered for a substantial time period after exposure to noise ceases. |
Databáze: | OpenAIRE |
Externí odkaz: |