Influence of -174G/C IL-6 gene polymorphism on the susceptibility to rheumatoid arthritis in children and adults in the Republic Of Belarus

Autor: D. V. Balshakova, V. E. Yagur, R. I. Goncharova, A. V. Sukalo, A. M. Tchitchko, H. A. Yatskiu
Rok vydání: 2018
Předmět:
Zdroj: Doklady of the National Academy of Sciences of Belarus. 62:608-614
ISSN: 2524-2431
1561-8323
DOI: 10.29235/1561-8323-2018-62-5-608-614
Popis: The usage of clinical and instrumental methods only may be not sufficient for early diagnosis of autoimmune rheumatic diseases, as well as for their course prediction. The progress of modern rheumatology is largely conditioned by the investigation of molecular-genetic nature of diseases and the identification of biomarkers that can significantly improve diagnostics and therapeutic approach. The present study aimed to evaluate the effect of -174G/C IL-6 gene polymorphism on the risk of developing rheumatoid arthritis (RA) in children and adults in Republic of Belarus. It was established that the CC genotype frequency (p = 0.01, OR = 2.19; 95 % CI [1.31-3.67]) as well as the С allele frequency (p = 0.03; OR = 1.44; 95 % CI [1.04-2.00]) was significantly higher among patients with juvenile idiopathic arthritis (JIA) in the entire group and especially in girls (p = 0.04, OR = 2.55; 95 % CI [1.22-5.36]) in comparison with the controls. In addition, there is a tendency to higher frequency of the С allele in adult patients with RA (p = 0.07), reaching statistical significance in the case of RF-negative arthritis (p = 0.03, OR = 3.04; 95 % CI [1.15-8.06]). The minor С allele (p = 0.03, OR = 2.04; 95 % CI [1.09-3.82]) and homozygous CC genotype (p = 0.02, OR = 3.34; 95 % CI [1.38-8.07]) are also associated with seronegative polyarthritis in children. Thus, the presence of this allele in the tested locus increases the likelihood of developing certain rheumatoid arthritis subtypes in adults and children and can be used to reveal individuals with genetic predisposition.
Databáze: OpenAIRE
Externí odkaz: