THE COORDINATION CHEMISTRY OF HNO: FROM WARREN ROPER TO HEMOGLOBIN

Autor:	Mugaresson R. Kumar, Elky Almaraz, Patrick J. Farmer
Rok vydání:	2010
Předmět:	Inorganic Chemistry chemistry.chemical_classification chemistry.chemical_compound chemistry Organic chemistry Bioinorganic chemistry Nitroxyl Nitrosyl hydride Coordination complex Adduct
Zdroj:	Comments on Inorganic Chemistry. 31:130-143
ISSN:	1548-9574 0260-3594
DOI:	10.1080/02603594.2010.520257
Popis:	The coordination chemistry of the one-electron reduced form of nitric oxide, termed a nitroxyl or nitrosyl hydride (NO- or HNO), is described anecdotally through the author's discovery of a stable HNO adduct of myoglobin, HNO-Mb, as an illustration of how different areas of chemistry, such as organometallic and bioinorganic, overlap and influence one another in unexpected ways. HNO is short-lived in solution, and many fundamental characteristics of HNO, such as the widely cited values of its oxidation potential and pKa, have been significantly revised through collaborations of theoreticians, biologists, and physical chemists. The very first HNO metal complex was discovered in Warren Ropers lab in 1970, with some 27 years before the next fully characterized example was reported by Hillhouse. Hillhouse in turn helped guide our characterization of HNO-Mb. As with oxymyoglobin, there are several possible descriptions of bonding for HNO-adducts, we present an analogy to the π-bonding interactions of a Fischer ...
Databáze:	OpenAIRE
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