Comparison of the main oesophageal pathophysiological characteristics between short- and long-segment Barrett's oesophagus

Autor:	Pietro Dulbecco, L. Tessieri, C. Gambaro, Carlo Mansi, R. Biagini, C. Bilardi, Patrizia Zentilin, Elena Iiritano, N. Pandolfo, Sergio Vigneri, M. Conio, Maria Raffaella Mele, Vincenzo Savarino
Rok vydání:	2002
Předmět:	medicine.medical_specialty Hepatology business.industry Esophageal disease digestive oral and skin physiology Gastroenterology Case-control study Reflux Intestinal metaplasia Long segment medicine.disease digestive system digestive system diseases Pathophysiology medicine.anatomical_structure Internal medicine otorhinolaryngologic diseases medicine Pharmacology (medical) Esophagus business Esophagitis
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:893-898
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01237.x
Popis:	Aim: To assess the oesophageal manometric characteristics and 24-h pH profiles of patients with both short-segment and long-segment Barrett's oesophagus and compare them with those of patients with reflux oesophagitis and controls. Methods: Seventy-nine patients who had undergone upper digestive endoscopy were recruited: 16 had short-segment Barrett's oesophagus, 13 had long-segment Barrett's oesophagus, 25 had grade III oesophagitis according to the Savary–Miller classification and 25 were used as controls. The diagnosis of Barrett's oesophagus was based on the histological detection of specialized intestinal metaplasia, which extended 3 cm in patients with long-segment disease. All subjects underwent oesophageal manometry and basal 24-h oesophageal pH monitoring. Results: The lower oesophageal sphincter pressure was significantly lower in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus than in controls (P=0.0004–0.0001), but there was no difference among the three reflux groups. The peristaltic wave amplitude of patients with long-segment Barrett's oesophagus was significantly lower than that of controls (P=0.002) and patients with short-segment Barrett's oesophagus (P=0.02), but was no different from that of patients with reflux oesophagitis. The percentage of non-propagated wet swallows was significantly higher in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus when compared with that of controls (P=0.0004–0.0001). The total percentage of time the oesophagus was exposed to pH
Databáze:	OpenAIRE
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