| Autor: |
Romain Sermet, Nicolas Piliero, Alicia Guillien, Simon Madoun, Stéphane Doutreleau, Muriel Salvat, Mathieu Finas, Frédéric Thony, Estelle Vautrin, Hélène Bouvaist, Bruno Degano |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ERJ Open Research. 9:00590-2022 |
| ISSN: |
2312-0541 |
| DOI: |
10.1183/23120541.00590-2022 |
| Popis: |
ObjectiveTo determine whether changes in pulmonary vascular resistance (PVR) and changes in pulmonary artery compliance (Cpa) are associated with changes in exercise capacity assessed either by changes in peak oxygen consumption (V′O2) or by changes in 6-min walk distance (6MWD) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing balloon pulmonary angioplasty (BPA).MethodsInvasive haemodynamic parameters, peakV′O2and 6MWD were measured within 24 h, before and after BPA (interval 3.1±2.4 months) in 34 CTEPH patients without significant cardiac and/or pulmonary comorbidities, of whom 24 received at least one pulmonary hypertension-specific treatment.Cpawas calculated according to the pulse pressure method:Cpa=((SV/PP)/1.76+0.1), where SV is the stroke volume and PP is the pulse pressure. The resistance–compliance (RC)-time of the pulmonary circulation was calculated as the PVR andCpaproduct.ResultsAfter BPA, PVR decreased (562±234versus290±106 dyn·s·cm−5; pCpaincreased (0.90±0.36versus1.63±0.65 mL·mmHg−1; pversus0.321±0.083 s; p=0.75). There were improvements in peakV′O2(1.11±0.35versus1.30±0.33 L·min−1; pversus432±100 m; pV′O2or 6MWD, were significantly associated with changes in PVR, but not with changes inCpa.ConclusionsContrary to what has been reported in CTEPH patients undergoing pulmonary endarterectomy, in CTEPH patients undergoing BPA, changes in exercise capacity were not associated with changes inCpa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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