Impregnation of Ultrahigh-Molecular-Weight Polyethylene with Amoxicillin in Subcritical Freon R22 Media
| Autor: | N. A. Tilkunova, M. I. Vlasov, M. V. Kiselevsky, I. V. Chernyshova, Fedor Senatov, N. Yu. Anisimova, T. S. Spirina, D. Yu. Zalepugin, A.V. Maksimkin |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Chromatography Freon 02 engineering and technology Polymer Amoxicillin Polyethylene 010402 general chemistry 021001 nanoscience & nanotechnology Bone tissue 01 natural sciences High-performance liquid chromatography 0104 chemical sciences Matrix (chemical analysis) chemistry.chemical_compound medicine.anatomical_structure chemistry Desorption medicine Physical and Theoretical Chemistry 0210 nano-technology medicine.drug |
| Zdroj: | Russian Journal of Physical Chemistry B. 11:1215-1222 |
| ISSN: | 1990-7923 1990-7931 |
| DOI: | 10.1134/s1990793117080152 |
| Popis: | The method of impregnation of ultrahigh-molecular-weight polyethylene (UHMWPE) with amoxicillin in subcritical Freon R22 media is developed. For the first time, the possibility of polymer impregnation with a polar substance (a standard antibiotic amoxicillin) in the absence of cosolvents is shown. Cosolvents increase the polarity of the medium and removal of them from the polymer matrix is usually a serious problem. Amoxicillin desorption curves from the impregnated UHMWPE samples are obtained by high-performance liquid chromatography (HPLC). Polymeric samples impregnated with amoxicillin are active against gram-positive and gram-negative microorganisms S. aureus, S. epidermidis, E. faecalis, B. subtilis, and E. coli, allowing them to be considered as real implant models for replacement of bone tissue. |
| Databáze: | OpenAIRE |
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