Effect of nano‐sized SiO2 particles on the cognitive function and biochemical response
| Autor: | Mohsen Sakly, Amara Salem, Amal Oudhabechi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty Health Toxicology and Mutagenesis education Morris water navigation task 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Cytotoxicity Pathological 0105 earth and related environmental sciences General Environmental Science Chemistry technology industry and agriculture Public Health Environmental and Occupational Health Cognition Histology medicine.disease 030210 environmental & occupational health In vitro Endocrinology Toxicity Infiltration (medical) |
| Zdroj: | Archives of Environmental & Occupational Health. 74:140-146 |
| ISSN: | 2154-4700 1933-8244 |
| DOI: | 10.1080/19338244.2018.1489365 |
| Popis: | Several in vitro studies have convincingly demonstrated that SiO2NPs mediated cytotoxicity, which was dose-, time- and size-dependent. The data on in vivo toxicity of SiO2NPs are even more contradictory. In the present study, we investigated the effects of sub-acute exposure to SiO2-NPs on spatial learning and memory, the biochemical parameters and the histology of organs. Rats were injected intravenously with a single dose of SiO2-NPs (20 mg/kg) during five consecutive days. The analysis of spatial memory in the Morris water maze showed that SiO2-NPs disrupt the cognitive abilities of rats. Moreover, SiO2-NPs could changes the blood counts. However, biochemical markers remained unchanged. Histological examination showed that SiO2-NPs induced pathological changes in rat organs. In this finding NPs were shown to cause granuloma formation and inflammatory cells infiltration in the liver. |
| Databáze: | OpenAIRE |
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