| Autor: |
G. Voggenreiter, St. Assenmacher, St. Leiting, H. Brauer |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Deutsche Gesellschaft für Chirurgie ISBN: 9783540417187 |
| DOI: |
10.1007/978-3-642-56698-1_103 |
| Popis: |
Titanium as a material for bone plates used in trauma surgery is supposed to be biologically inert. Since we were able to observe metallosis when removing titanium plates, we decided to study the tissue reaction histologically and to compare it to the reaction to stainless steel. We examined the immuno-inflammatory response to titanium plates by means of immunohistochemical methods in 15 patients with implants made of titanium and in 20 patients with implants made of stainless steel. No patient had an infection during fracture healing. In the soft tissue adjacent to the surface of titanium implants and to the surface of implants made of stainless steel, particles were observed in all cases, which were located in macrophages (CD68+). Most of them expressed MHC class II as a sign of activation. T-lymphocytes (CD45RO+) were detected in the vicinity of titanium particles and some of them were also CD8-positive. B-lymphocytes (CD79α+) were absent. This tissue reaction could be observed both in the case of titanium implants and in the case of steel implants. We were able to detect the same kind of immunocompetent cells and semiquantitative analysis showed no differences either. The presence of titanium and stainless steel was confirmed by energy-dispersive X-ray analysis. The observed tissue reaction to bone plates made of titanium shows that titanium is not really inert. The question of whether such bone plates should be removed has to be discussed for each patient individually. In the future, further improvement of the materials used in trauma surgery is necessary. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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