SAT0293 Serum and Tear Cytokines and Chemokines Levels as Disease Activity Biomarkers in Patients with Primary Sjögren's Syndrome
| Autor: | M.A. Moreno Eutimio, M.E. Vélez Cruz, N.G. Nieto Velázquez, C. Liceaga Escalera, A. Castillo Ortiz, R. E. Barbosa Cobos, L.T. Becerril Mendoza, L.A. Montoya Pérez, G. E. Lugo Zamudio, A.A. Tzec Pérez |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Saliva Chemokine biology business.industry medicine.medical_treatment Immunology Arthritis medicine.disease General Biochemistry Genetics and Molecular Biology Rheumatology Pathogenesis Cytokine Internal medicine biology.protein Immunology and Allergy Medicine Biomarker (medicine) Tumor necrosis factor alpha business |
| Zdroj: | Annals of the Rheumatic Diseases. 75:774.2-774 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | Background Evidence suggests that levels of different cytokines in primary Sjogren9s syndrome (pSS) are associated with cell infiltration degree within salivary and lacrimal glands and severity of the disease. Chemokines appear to contribute to the pathogenesis of pSS. Objectives To evaluate the association between serum and salivary Th1/Th2/Th17 cytokines and chemokines leves and disease activity in patients with pSS. Methods Case-control study, 18 patients with pSS and 13 healthy controls were included. Disease activity was assessed by EULAR Sjogren9s Syndrome Disease Activity Index (ESSDAI); serum and salivary IFN-γ, TNF, IL-2, IL-4, IL-6, IL-10, IL-17, IP10, MCP-1, MIG, RANTES and IL-8 levels were measured by bead-based assays following the sandwich immunoassay principle (BD Cytometric Bead Array; BD Biosciences). Differences between groups were analyzed using the Mann-Whitney U test, correlation was estimated by Spearman9s correlation coefficient. Results IL-17, IL-2, IL-4, IFNγ, MIG and RANTES salivary levels were statistically different between controls and patients with pSS (p Conclusions Increased salivary Th1/Th2/Th17 cytokines and chemokines levels were found in pSS. No correlation was found between serum or salivary cytokines and chemokines levels and pSS disease activity. References Chen W, Cao H, Lin J, Olsen N, Zheng SG. Biomarkers for primary Sjogren syndrome. Genomics Proteomics Bioformatics 2015; 11:219–23. Bikker A, Moret FM, Kruize AA, Bijlsma JW, Lafeber FP, van Roon JA. IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα. Rheumatology Oxford 2012; 51: 996–1005. Lee YJ, Scofield RH, Hyon JY, Yun PY, Lee HJ, Lee EY, Lee EB, Song YW. Salivary chemokine levels in patients with primary Sjogren9s syndrome. Rheumatology Oxford. 2010; 49:1747–52. Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. Systemic and local interleukin-17 and linked cytokines associated with Sjogren9s syndrome immunopathogenesis. Am J Pathol 2009; 175:1167–1177. Delaleu N, Immervoll H, Cornelius J, Jonsson R. Biomarker profiles in serum and saliva of experimental Sjogren9s syndrome: associations with specific autoimmune manifestations. Arthritis Res Ther 2008; 10:1–14. Disclosure of Interest None declared |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|