CNTNAP2is a direct FoxP2 targetin vitroandin vivoin zebra finches: complex regulation by age and activity
| Autor: | Iris Adam, Ursula Kobalz, Constance Scharff, Ezequiel Mendoza, Sandra Wohlgemuth |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CNTNAP2 animal structures biology FOXP2 Neurotransmission biology.organism_classification Songbird 03 medical and health sciences Behavioral Neuroscience 030104 developmental biology 0302 clinical medicine nervous system Neurology Downregulation and upregulation Basal ganglia behavior and behavior mechanisms Genetics Vocal learning Zebra finch Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Genes, Brain and Behavior. 16:635-642 |
| ISSN: | 1601-1848 |
| DOI: | 10.1111/gbb.12390 |
| Popis: | Mutations of FOXP2 are associated with altered brain structure, including the striatal part of the basal ganglia, and cause a severe speech and language disorder. Songbirds serve as a tractable neurobiological model for speech and language research. Experimental downregulation of FoxP2 in zebra finch Area X, a nucleus of the striatal song control circuitry, affects synaptic transmission and spine densities. It also renders song learning and production inaccurate and imprecise, similar to the speech impairment of patients carrying FOXP2 mutations. Here we show that experimental downregulation of FoxP2 in Area X using lentiviral vectors leads to reduced expression of CNTNAP2, a FOXP2 target gene in humans. In addition, natural downregulation of FoxP2 by age or by singing also downregulated CNTNAP2 expression. Furthermore, we report that FoxP2 binds to and activates the avian CNTNAP2 promoter in vitro. Taken together these data establish CNTNAP2 as a direct FoxP2 target gene in songbirds, likely affecting synaptic function relevant for song learning and song maintenance. |
| Databáze: | OpenAIRE |
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