Etanercept Treatment in Sweet’s Syndrome with Inflammatory Arthritis
| Autor: | Donough Howard, Nicola Ambrose, Anne-Marie Tobin |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | The Journal of Rheumatology. 36:1348.2-1349 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.080698 |
| Popis: | To the Editor: A 55-year-old Caucasian man initially presented 6 years earlier to an outside facility with a photosensitive rash, arthritis, fatigue, and mild neutrophilia. He had a history of liver cirrhosis, felt to be secondary to previous alcohol consumption. He had several inflammatory papules and plaques on his trunk and forearms that clinically were suggestive of Sweet’s syndrome. A skin biopsy showed a dense, perivascular, neutrophilic infiltrate, which confirmed the diagnosis1. He was prescribed prednisolone and a calcium-vitamin D3 preparation. Standard investigations for an underlying malignancy were undertaken2, with results that were normal. Both his arthritis and his skin disease improved dramatically under steroid treatment, but both flared again once the steroid dose was tapered below 20 mg per day. Over the next 5 years he was followed up by a dermatology service and was maintained on 20–40 mg prednisolone. Concomitant treatment with colchicine, hydroxychloroquine, and chloroquine was ineffective, nonsteroidal antiinflammatory drugs were not tolerated because of gastrointestinal side effects, and liver … Address reprint requests to Dr. Ambrose; E-mail: nambrose2001{at}yahoo.co.uk |
| Databáze: | OpenAIRE |
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