Synthesis of novel metal (II) complexes tailored from 9-oxo-9H-fluorene-1-carboxylic acid via green protocol: DNA cleavage and anticancer studies
| Autor: | Sangamesh A. Patil, Arun Kashivishwanath Shettar, Shivakumar S. Toragalmath, Shailaja S. Jawoor, Mahantesh Kumbar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gel electrophoresis
chemistry.chemical_classification 010405 organic chemistry Ligand Carboxylic acid 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Inorganic Chemistry Metal chemistry.chemical_compound Deprotonation Transition metal Fluorenone chemistry visual_art Materials Chemistry visual_art.visual_art_medium Physical and Theoretical Chemistry Carcinogen |
| Zdroj: | Inorganica Chimica Acta. 500:119210 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/j.ica.2019.119210 |
| Popis: | Despite being a polycyclic aromatic compound, fluorenone is not classified as carcinogenic. Some of the derivatives of fluorenone and metal complexes embedded with fluorenone based ligands exhibited challenging biological activities, including anticancer activity. The current investigation hence focuses on synthesis, characterization and anticancer activities of fluorenone based ligands and their coordinate compounds of some first row transition metals. The stoichiometry of all the synthesized metal complexes is found to be 1: 2 (metal: ligand) with the general formula [M(L)2], L = singly deprotonated ligand, whereas the geometry of all the metal complexes is found to be octahedral. The synthesized ligands and their respective metal (II) complexes were found to cleave the pBR322 DNA, during gel electrophoresis studies. The inhibition of cancer cell growth has been confirmed by fluorescence imaging techniques using DAPI as staining dye. The IC50 values of ligands and their metal (II) complexes suggest that synthesized compounds are more active towards A549 (human lung adenocarcinoma) cell line when compared with the standard drug Paclitaxel. In case of MCF-7 (human breast carcinoma) cell line, compound Cu(L2)2 is found to be more active than the standard drug Paclitaxel. |
| Databáze: | OpenAIRE |
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