ChemInform Abstract: Synthesis of Isoindolo[1,4]benzoxazinone and Isoindolo[1,5]benzoxazepine: Two New Ring Systems of Pharmaceutical Interest
Autor: | Alessandra Montalbano, Patrizia Diana, Anna Carbone, Barbara Parrino, Paola Barraja, Virginia Spanò, Cristina Ciancimino, Girolamo Cirrincione |
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Rok vydání: | 2016 |
Předmět: | |
Zdroj: | ChemInform. 47 |
ISSN: | 0931-7597 |
Popis: | Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM). |
Databáze: | OpenAIRE |
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