ChemInform Abstract: Synthesis of Isoindolo[1,4]benzoxazinone and Isoindolo[1,5]benzoxazepine: Two New Ring Systems of Pharmaceutical Interest

Autor:	Alessandra Montalbano, Patrizia Diana, Anna Carbone, Barbara Parrino, Paola Barraja, Virginia Spanò, Cristina Ciancimino, Girolamo Cirrincione
Rok vydání:	2016
Předmět:	Human tumor chemistry.chemical_compound chemistry General Medicine Isoindole Ring (chemistry) Combinatorial chemistry
Zdroj:	ChemInform. 47
ISSN:	0931-7597
Popis:	Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::44eca61d66fe5562deee8a0ef21b0f6a https://doi.org/10.1002/chin.201601183 Zobrazit plný text záznamu Plný text