Hypofractionated irradiation of the solid form of Ehrlich ascites carcinoma in mice by a thin scanning proton beam
| Autor: | N. S. Strelnikova, Smirnova En, S. P. Romanchenko, V. E. Balakin, Zaichkina Si, S. S. Sorokina, O. M. Rozanova, A. E. Shemyakov |
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| Rok vydání: | 2016 |
| Předmět: |
Proton
business.industry Chemistry Biophysics Planning target volume Bragg peak 030218 nuclear medicine & medical imaging Ehrlich ascites carcinoma Gross tumor volume 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Irradiation Nuclear medicine business Beam (structure) |
| Zdroj: | Biophysics. 61:682-686 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350916040047 |
| Popis: | The dynamics of the growth of Ehrlich ascites carcinoma in mice of the SHK line exposed to hypofractionated high-dose irradiation by a thin scanning proton beam has been analyzed for different irradiation volumes and different time intervals (from 4 to 24 hours) between two 30-Gy fractions. Irradiation of the gross tumor volume and the planned target volume was performed within the Bragg peak; the energy of protons at the outlet of the accelerator ranged from 85 to 100 MeV. Hypofractionated irradiation of the gross tumor volume of Ehrlich ascites carcinoma resulted in a more pronounced antitumor effect than the irradiation of the planned target volume. The effect did not depend on the interval between the irradiation episodes. |
| Databáze: | OpenAIRE |
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