Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge
| Autor: | Barbara Poore, Mike Piatak, Jeffrey L. Rossio, Vicky Coalter, Elena Chertova, Robert J. Imming, J. D. Lifson, Larry O. Arthur, Ronald C. Desrosiers, Julian W. Bess, Rebecca Kiser, Louis E. Henderson, Douglas K. Schneider |
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| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
Immunogen General Veterinary animal diseases viruses medicine.medical_treatment Immunogenicity Mutant virus diseases biochemical phenomena metabolism and nutrition Simian immunodeficiency virus Biology medicine.disease_cause Virology Antibody response chemistry medicine Animal Science and Zoology Glycoprotein Adjuvant CD8 |
| Zdroj: | Journal of Medical Primatology. 31:205-216 |
| ISSN: | 0047-2565 |
| DOI: | 10.1034/j.1600-0684.2002.02007.x |
| Popis: | A novel type of whole inactivated simian immunodeficiency virus (SIV) virion vaccine immunogen with functional envelope glycoproteins was evaluated, without adjuvant, in rhesus macaques. Immunogens included purified inactivated virions of SIVmac239, a designed mutant of SIVmac239 with gp120 carbohydrate attachment sites deleted (SIVmac239 g4,5), and SIVmneE11S. The vaccines were noninfectious, safe, and immunogenic, inducing antibody responses and cellular responses, including responses by CD8+ lymphocytes. Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naive controls. |
| Databáze: | OpenAIRE |
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